The US Food and Drug Administration approved of the NIAID-funded study.
This study will look at 2 new studies that will be run within a 1 yr cycle (May 2014 – March 2016).
The studies will be in mice and rats.
Both of these studies will investigate the effects of the NIAID-funded research on human behavior and cognition.
What are the study procedures?
We will be doing 2 studies at Johns Hopkins.
One study of mice is run 1 yr prior to the 1 yr human study.
The other study of rats is run 1 yr before the 1 yr human study.
What are the mice and rats?
The mice will be two groups of animals – male-female pairs – weighing 25.5 – 33 pounds each.
Each group will have had 10 day prior to the study a surgical procedure which will be to remove all of the brain matter.
In each group a single dose of 2mg/kg of S-adenosylmethionine (SAMe) will be given over 8 weeks.
Both mice and rats also have been given the NIDOL
The rats will be bred to obtain a diet that results in only 1/200 (12.5%) of their body weight coming from protein and fat.
A separate group will have consumed 2mg/kg of S-adenosyl-methionine (SAMe) every day for 8 weeks during which time they have been given a blood test which measures SAMe in their blood.
How is the food designed to test for SAMe?
We will make sure that the diet is nutritionally adequate to achieve the best possible outcome for the rats.
What are the parameters of the food and the study?
The Food Supplement of this study is a mixture of high-quality raw materials which are in the same level of quality as natural foods.
The mice and rats will be fed a diet with 0 to 100% calories per gram. It is important to maintain the calories provided to avoid obesity and develop proper levels of nutrients.
The rats will also be given a blood glucose level at the beginning of each test period.
The study will cover all of the parameters that have been observed in human studies.
Will the animals also have the NIDOL taken in the diet?
The NIDOL is in the diet for the rats because
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